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Product Name Nur77 Chinese Name 孤儿核受体蛋白Nur77Recombinant rabbit monoclonal anti Alias GFRP 1; GFRP; GFRP1; Growth factor inducible nuclear protein N10; Growth Factor Inducible Nuclear Protein NP10; Growth Factor Response Protein 1; Hbr1; HMR; Hormone Receptor; MGC9485; N10; N10 nuclear protein; NAK 1; NAK1; NGFIB; NP 10; NP10; NR4A1; Nuclear hormone receptor NUR/77; Nuclear Hormone Receptor TR3; Nuclear Receptor Subfamily 4 Group A Member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor NR4A1; ST 59; ST59; Steroid receptor TR3; TR 3; TR3; TR3 orphan receptor; Early response protein NAK1. Immunogen Species Rabbit Clonality Monoclonal Clone NO. 1C1 React Species (predicted: Human, Mouse, Rat, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 66kDa Cellular localization The nucleus Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Nur77 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Function:
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.
Subunit:
Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Fetal muscle and adult liver, brain and thyroid.
Post-translational modifications:
Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.
Similarity:
Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain.
SWISS:
P22736
Gene ID:
3164
Database links:Entrez Gene: 3164 Human
Entrez Gene: 15370 Mouse
Omim: 139139 Human
SwissProt: P22736 Human
SwissProt: P12813 Mouse
Unigene: 524430 Human
Unigene: 119 Mouse
Unigene: 10000 Rat
孤儿核受体蛋白Nur77是早期反应转录因子之一,多种刺激因子如缺氧可诱导其迅速表达,Nur77参与调控细胞增殖、存活、分化等过程。这类核受体是体内广泛分布的配体依赖性的转录因子,通过调控基因协调表达,在机体的生长发育、The new supersedes the old,Cell differentiation及体内许多生长发育过程中发挥重要作用,其功能障碍将导致一系列疾病的发生,如;癌症、Diabetes、肥胖、不孕不育等等。
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