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Product Name TGN46 Chinese Name 高尔基体网络整合膜蛋白Recombinant rabbit monoclonal anti Alias TGN 46; TGN 51; TGN38; TGN38 homolog; TGN38B; TGN46; TGN48; TGN51; TGOLN2; TGON2_HUMAN; Trans Golgi network integral membrane protein 2; Trans golgi network protein 2; Trans Golgi network protein TGN51; Trans-Golgi network integral membrane protein 1; Trans-Golgi network integral membrane protein 2; Trans-Golgi network protein TGN51; TTGN2. Immunogen Species Rabbit Clonality Monoclonal React Species Human, (predicted: Mouse, ) Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Form Lyophilized or Liquid Concentration 1mg/ml Lsotype IgG Purification affinity purified by Protein A Buffer Solution 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Function:
May be involved in regulating membrane traffic to and from trans-Golgi network.
Subcellular Location:
Cell membrane. Golgi apparatus > trans-Golgi network membrane. Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.
Tissue Specificity:
Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.
SWISS:
O43493
Gene ID:
10618
Database links:Entrez Gene: 10618 Human
Omim: 603062 Human
SwissProt: O43493 Human
Unigene: 593382 Human
Unigene: 11349 Rat
Product Picture Sample:
Lane 1: Human MCF-7 cell lysates
Lane 2: Human MDA-MB-231 cell lysates
Lane 3: Human HeLa cell lysates
Lane 4: Human HepG2 cell lysates
Lane 5: Human U251 cell lysates
Lane 6: Human A549 cell lysates
Primary: Anti-TGN46 (SLM-54769R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: kDa
Observed band size: 95 kDa
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