Product Name	PTPN12
Chinese Name	酪氨酸蛋白磷酸酶非受体型12Recombinant rabbit monoclonal anti
Alias	PTN12_HUMAN; Tyrosine-protein phosphatase non-receptor type 12; EC:3.1.3.48; PTP-PEST; Protein-tyrosine phosphatase G1 (PTPG1); protein tyrosine phosphatase non-receptor type 12; PTPG1; PTP-PEST;
Research Area	Cell biology  Chromatin and nuclear signals  Epigenetics
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	R2C6
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	88kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PTPN12
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] Subcellular Location: Cytoplasm. SWISS: Q05209 Gene ID: 5782 Database links: Entrez Gene: 5782 Human Entrez Gene: 19248 Mouse Entrez Gene: 117255 Rat SwissProt: Q05209 Human SwissProt: P35831 Mouse SwissProt: Q63745 Rat

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