Product Name	GAB1
Chinese Name	接头蛋白Gab 1Recombinant rabbit monoclonal anti
Alias	GAB1_HUMAN; GRB2-associated-binding protein 1; GAB1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1;
Research Area	Tumour  Cell biology  Signal transduction  Apoptosis  Cyclin  Kinases and Phosphatases  The cell membrane受体  Cell differentiation
Immunogen Species	Rabbit
Clonality	Monoclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 IHC-P=1:100-500 ICC=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	76kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human GAB1
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity (1-3,8). Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF. Function: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Subunit: Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Similarity: Belongs to the GAB family. Contains 1 PH domain. SWISS: Q13480 Gene ID: 2549 Database links: Entrez Gene: 2549 Human Entrez Gene: 14388 Mouse Entrez Gene: 361388 Rat SwissProt: Q13480 Human SwissProt: Q9QYY0 Mouse Gab1作为一种分布广泛的接头蛋白，几乎能连接所有类型的受体（如酪氨酸激酶受体、G-蛋白偶联受体、cell factor与抗原受体等，Gab1蛋白属于接头蛋白Gab家族,该家族蛋白因能与生长因子受体Binding protein2（Grb2）相结合而得名。作为接头蛋白,Gab1蛋白能被多种受体酪氨酸激酶或非受体酪氨酸激酶激活,接受胞外多种生长因子、cell factor和一些T/B细胞抗原受体的刺激,介导PI3K/Akt和Ras/MAPK等多条Signal transduction途径,具有促进细胞生长、迁移、调节免疫等多种生物学功能,与Diabetes、Tumour、Cardiovascular疾病等的发生发展密切相关。

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