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Product Name SOX1 Chinese Name 转录因子SOX-1Recombinant rabbit monoclonal anti Alias SOX1_HUMAN; Transcription factor SOX-1; SRY-box transcription factor 1; Research Area Developmental biology Neurobiology Stem cells transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Monoclonal Clone NO. 23C9 React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-1000 IHC-P=1:100-500 ICC=1:50-100 IF=1:50-100 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 39kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen Recombinant human SOX1 protein (100-200aa) Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Function:
Transcriptional activator.
Subcellular Location:
Nucleus.
Tissue Specificity:
Mainly expressed in the developing central nervous system.
Post-translational modifications:
Sumoylation inhibits the transcriptional activity.
Similarity:
Contains 1 HMG box DNA-binding domain.
SWISS:
O00570
Gene ID:
6656
Database links:Entrez Gene: 6656 Human
Entrez Gene: 20664 Mouse
Omim: 602148 Human
SwissProt: O00570 Human
SwissProt: P53783 Mouse
Unigene: 202526 Human
Unigene: 39088 Mouse
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