Product Name	PDHA1
Chinese Name	Runx3Recombinant rabbit monoclonal anti
Alias	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; ODPA_HUMAN; EC:1.2.4.1; PDHE1-A type I; pyruvate dehydrogenase E1 subunit alpha 1; PDHA; PDHAD; PHE1A; E1alpha; PDHCE1A; PDH-E1α;
Research Area	Mitochondrion
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	R9B7
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDHA1
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010] Subcellular Location: Mitochondrion matrix. Tissue Specificity: Testis. Expressed in postmeiotic spermatogenic cells. SWISS: P08559 Gene ID: 5160 Database links: Entrez Gene: 5160 Human Entrez Gene: 18597 Mouse Entrez Gene: 29554 Rat SwissProt: P08559 Human SwissProt: P35486 Mouse SwissProt: P26284 Rat
Product Picture	Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: HeLa, 2: Mouse kidney, 3: Rat kidney Protein loading quantity: 20 μg Exposure time: 30 s Predicted MW: 43 kDa Observed MW: 43 kDa

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