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Product Name Granzyme B Chinese Name 颗粒酶B单克隆抗体 Alias GranzymeB; Granzyme-B; C11; Cathepsin G-like 1; CTLA-1; Cathespin G Like 1; CCPI; CCP-1; CGL 1; CGL1; CSP B; CSPB; CTLA 1;CTLA1; CTSGL 1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T Lymphocyte Associated Serine Esterase 1; Cytotoxic T lymphocyte proteinase 2; Fragmentin 2; Fragmentin2; Granzyme 2; Granzyme2; GRB; GZMB; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; GRAB_HUMAN; Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1); Granzyme B; Granzyme-2; GranzymeB; HLP; T cell serine protease 1 3E; T cell serine protease 1-3E; T-cell serine protease 1-3E; HLP; Human lymphocyte protein; Lymphocyte protease; Protease Serine B; SECT; AA 18-29; T cell serine protease 1. Immunogen Species Mouse Clonality Monoclonal React Species (predicted: Human, ) Applications WB=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 25kDa Cellular localization Extracellular matrix Secretory protein Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GZMB Lsotype IgG2a, κ Purification affinity purified by Protein A Buffer Solution PBS, Glycerol, BSA Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]
Function:
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location:
Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Similarity:
Belongs to the peptidase S1 family. Granzyme subfamily. Contains 1 peptidase S1 domain.
SWISS:
P10144
Gene ID:
3002
Database links:Entrez Gene: 3002 Human
Entrez Gene: 14939 Mouse
Omim: 123910 Human
SwissProt: P10144 Human
SwissProt: P04187 Mouse
Unigene: 1051 Human
Unigene: 14874 Mouse
Unigene: 132115 Rat
Unigene: 145789 Rat
Unigene: 21395 Rat
Granzyme B—是一种丝氨酸蛋白酶,作用在Apoptosis中。
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