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Product Name SLC10A2 Chinese Name 顶膜钠依赖性胆盐转运体蛋白抗体 Alias SLC10A2; Apical sodium dependent bile acid transporter; Apical sodium- dependent bile acid transporter; Ileal sodium dependent bile acid transporter; Ileal sodium-dependent bile acid transporter; Ileal sodium/bile acid cotransporter; ISBT; Na+ bile acid cotransporter; Na+ dependent ileal bile acid transporter; NTCP2; Sodium/taurocholate cotransporting polypeptide, ileal; solute carrier family 10 (sodium/bile acid cotransporter family); Solute carrier family 10 member 2. Research Area Tumour immunology Signal transduction Channel protein Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 38kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen Recombinant mouse SLC10A2 protein: 306-348/348 <Cytoplasmic> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail SLC10A2 plays a critical role in reabsorption of bile acids from the the small intestine lumen. Passive flow of sodium ions down their concentration gradient is coupled to bile acid movement, resulting in an increase in the concentration of bile acids in the interior of the cell. This action conserves the body's pool of re-circulating bile acid. SLC10A2 also plays a key role in cholesterol metabolism as cholesterol is the precursor molecule in bile acid synthesis mediated by CYP7A and FXR.
SWISS:
Q12908
Gene ID:
6555
Database links:
Entrez Gene: 6555 Human
Entrez Gene: 20494 Mouse
Omim: 601295 Human
SwissProt: Q12908 Human
SwissProt: P70172 Mouse
Unigene: 194783 Human
Unigene: 3500 Mouse
Unigene: 85891 Rat
Product Picture Sample:
Lane 1: Human LOVO cell lysates
Lane 2: Human SW480 cell lysates
Lane 3: Human 293T cell lysates
Primary: Anti-SLC10A2 (SL41358R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38 kDa
Observed band size: 46 kDa
Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SLC10A2) Polyclonal Antibody, Unconjugated (SL41358R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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