Product Name	HES1
Chinese Name	转录因子HES-1抗体
Alias	bHLHb39; C-HAIRY1; c-hairy1A; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1 (Drosophila); Hairy and enhancer of split 1; Hairy Enhancer of Split 1; Hairy homolog (Drosophila); Hairy Homolog; Hairy like; Hairy, Drosophila, homolog of; Hairy-like protein; Hairy/enhancer of split, Drosophila, homolog of, 1; HAIRY1; HES-1; hes1; Hes1 hairy and enhancer of split 1 (Drosophila); HES1_HUMAN; HHL; HL; HRY; RHL; Transcription factor HES 1; Transcription factor HES-1.
Research Area	immunology  Chromatin and nuclear signals  Neurobiology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	30kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human HES1 protein : 1-277/280
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. SWISS: Q14469 Gene ID: 3280 Database links: Entrez Gene: 395128 Chicken Entrez Gene: 539547 Cow Entrez Gene: 3280 Human Entrez Gene: 15205 Mouse Entrez Gene: 100499567 Pig Entrez Gene: 29577 Rat Omim: 139605 Human SwissProt: O57337 Chicken SwissProt: Q3ZBG4 Cow SwissProt: Q14469 Human SwissProt: P35428 Mouse SwissProt: Q04666 Rat Unigene: 250666 Human Unigene: 390859 Mouse Unigene: 19727 Rat
Product Picture	Sample: Lane 1: Recombinant human HES1 protein Primary: Anti-HES1 (SL41372R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 30 kDa Observed band size: 30 kDa Sample: Lane 1: Rat Kidney tissue lysates Lane 2: Rat Liver tissue lysates Primary: Anti-HES1 (SL41372R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 30 kDa Observed band size: 35 kDa Measured by its binding ability in a indirect ELISA. Immobilized Human HES1 protein, His Tag (Cat. SL41372P) at 2 μg/mL (100 μL/well) can bind  Rabbit Anti-Human HES1 Antibody, the EC50 is 178.8 ng/mL.

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