Product Name	PDE1B
Chinese Name	磷酸二酯酶1B抗体
Alias	5''-cyclic nucleotide phosphodiesterase 1B; 63 kDa Cam PDE; 63 kDa Cam-PDE; Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B; Calcium/calmodulin stimulated cyclic nucleotide phosphodiesterase; Calcium/calmodulin-dependent 3''; Calcium/calmodulin-dependent 3'5'-cyclic nucleotide Phosphodiesterase 1B; Calmodulin stimulated phosphodiesterase PDE1B1; Cam PDE 1B; Cam PDE1B; Cam-PDE 1B; PDE 1B; PDE1B; PDE1B_HUMAN; PDE1B1; PDES 1B; PDES1B; Phosphodiesterase 1B; Phosphodiesterase 1B calmodulin dependent; Phosphodiesterase 1B calmodulin-dependent; Presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	61kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDE1B: 451-536/536
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. Subcellular Location: Cytoplasm. Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. SWISS: Q01064 Gene ID: 5153 Database links: Entrez Gene: 5153 Human Entrez Gene: 18574 Mouse Entrez Gene: 29691 Rat Omim: 171891 Human SwissProt: Q01064 Human SwissProt: Q01065 Mouse SwissProt: Q01066 Rat Unigene: 530871 Human Unigene: 390792 Mouse Unigene: 53489 Rat
Product Picture	Sample: Lane 1: Human 293T cell lysates Lane 2: Human SH-SY5Y cell lysates Lane 3: Human U251 cell lysates Primary: Anti-PDE1B (SL9968R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61 kDa Observed band size: 62 kDa Paraformaldehyde-fixed, paraffin embedded (human cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PDE1B) Polyclonal Antibody, Unconjugated (SL9968R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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