Product Name	BRD8
Chinese Name
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	B5F5
React Species	(predicted: Human, )
Applications	WB=1:200-1:1000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2a/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	在激素激活的核受体（NR）的转录激活过程中可能作为一个辅激活子。亚型2通过AR/DHTR、ESR1/NR3A1、RXRA/NR2B1和THRB/ERBA2刺激转录激活。亚型1和亚型2是NuA4组蛋白乙酰转移酶（HAT）复合物的组成部分，该复合物主要通过核小体组蛋白H4和H2A的乙酰化参与选择基因的转录激活。这种修饰可能改变核小体与DNA的相互作用，并促进修饰组蛋白与其他组蛋白的相互作用正调控转录的蛋白质。这种复合物可能是激活与癌基因和原癌基因介导的生长诱导、抑癌基因介导的生长停滞和复制性衰老、凋亡和DNA修复相关的转录程序所必需的。当被招募到DNA损伤部位时，NuA4也可能在DNA修复中发挥直接作用。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 4°C overnight Lysate: 1: HeLa, 2: HeLa nuclear Protein loading quantity: 20 μg Exposure time: 30 s Predicted MW: 120 kDa Observed MW: 120 kDa Tissue: Human colon cancer Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:100 Primary Ab incubation condition: 1 hour at room temperature Counter stain: Hematoxylin Comment: Color brown is the positive signal for SLM-60358M

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