Product Name	BTK
Chinese Name
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	B11A10
React Species	(predicted: Human, )
Applications	WB=1:1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	非受体酪氨酸激酶对Blymphocyte的发育、分化和信号传导必不可少。抗原与B细胞抗原受体（BCR）结合触发信号，最终导致B细胞活化。在BCR与质膜结合和活化后，PLCG2在多个位点磷酸化，通过钙动员激活下游信号通路，然后激活蛋白激酶C（PKC）家族成员。PLCG2磷酸化是在与适配器蛋白B细胞连接蛋白BLNK密切合作下进行的。BTK作为一个平台将不同的信号蛋白组合在一起，并与cell factor受体信号通路有关。作为Toll样受体（Toll-like receptors，TLR）通路的一个组成部分，在先天免疫和适应性免疫的免疫细胞功能中发挥着重要作用。TLR通路是检测病原体的主要监测系统，对激活宿主防御系统至关重要。

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