Product Name	ATR
Chinese Name
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	A5B4
React Species	(predicted: Human, )
Applications	WB=1:1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	丝氨酸/苏氨酸蛋白激酶，在基因毒性应激（如电离辐射（IR）、紫外线（UV）或DNA复制停滞）时激活检查点信号，从而充当DNA损伤传感器。识别底物共有序列[ST]-Q。磷酸化BRCA1、CHEK1、MCM2、RAD17、RPA2、SMC1和p53/TP53，共同抑制DNA复制和有丝分裂，促进DNA修复、重组和凋亡。在DNA损伤部位磷酸化组蛋白变体H2AX的“Ser-139”，从而调节DNA损伤反应机制。FANCD2Ubiquitin化所需。对维持脆弱位点的稳定性和中心体复制的有效调控至关重要。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Lysate: HeLa, MCF7, HepG2, A549, Jurkat Protein loading quantity: 20 μg Exposure time: 180 s Predicted MW: 300 kDa Observed MW: 240 kDa

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