Product Name	MTCO2
Chinese Name	细胞色素c氧化酶亚型2单克隆抗体
Alias	COX2_HUMAN; Cytochrome c oxidase subunit 2; EC:7.1.1.9; Cytochrome c oxidase polypeptide II; mitochondrially encoded cytochrome c oxidase II; MT-CO2; COII; COX2; COXII;
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	F10B1
React Species	(predicted: Human, )
Applications	WB=1:500-1:1000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2a/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Contributes to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and positive regulation of vasoconstriction. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Biomarker of Huntington's disease and stomach cancer. [provided by Alliance of Genome Resources, Apr 2022] Subcellular Location: Mitochondrion inner membrane; Multi-pass membrane protein. SWISS: P00403 Gene ID: 4513 Database links: Entrez Gene: 4513 Human SwissProt: P00403 Human 细胞色素c氧化酶的组成部分，是Mitochondrion电子传递链中最后一个推动氧化磷酸化的酶。呼吸链包含3个多亚单位复合物琥珀酸脱氢酶（复合体II，CII）、泛醌细胞色素c氧化还原酶（细胞色素b-c1复合物，复合体III，CIII）和细胞色素c氧化酶（复合体IV，CIV），它们协同将NADH和琥珀酸衍生的电子转移到分子氧中，在内膜上形成一个电化学梯度来驱动跨膜转运和ATP合成酶。细胞色素c氧化酶是也是呼吸链的组成部分，催化氧气还原为水。在膜间空间（IMS）中，来自还原细胞色素c的电子通过亚基2的双核铜A中心（CU（A））和亚单位1的血红素A转移到亚单位1中的活性位点，亚基1是由血红素A3和铜B（CU（B））形成的双核中心（BNC）。BNC利用IMS中细胞色素c的4个电子和Mitochondrion基质中的4个质子将分子氧还原为2个水分子。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 4°C overnight Secondary ab: Goat Anti-Mouse IgG H&L (HRP) Lysate: HepG2, HeLa Protein loading quantity: 20 μg Exposure time: 180 s Predicted MW: 20 kDa Observed MW: 20 kDa Tissue: Human kidney Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:200 Primary ab incubation condition: 1 hour at room temperature Secondary ab: SP Kit(Mouse)(sp-0024) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60259M Tissue: Human colon Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:200 Primary ab incubation condition: 1 hour at room temperature Secondary ab: SP Kit(Mouse)(sp-0024) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60259M Tissue: Human colon cancer Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:200 Primary ab incubation condition: 1 hour at room temperature Secondary ab: SP Kit(Mouse)(sp-0024) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60259M

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