Product Name	SMARCA5
Chinese Name	SMARCA5单克隆抗体
Alias	SMCA5_HUMAN; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; WCRF135; EC:3.6.4.-; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; Sucrose nonfermenting protein 2 homolog (hSNF2H); SNF2H;
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	B2A2
React Species	(predicted: Human, )
Applications	WB=1:500-1:2000 ICC=1:50-1:100  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	122kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2b/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008] Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed. SWISS: O60264 Gene ID: 8467 Database links: Entrez Gene: 8467 Human SwissProt: O60264 Human 解旋酶具有内在的ATP依赖性核小体重构活性。含有SmarC5的配合物能够在染色质上形成有序的核小体阵列，这可能需要完整的组蛋白H4尾部。参与在S期复制周着丝粒异染色质，特别是与BAZ1A结合。可能通过向rDNA启动子招募SIN3/HDAC1复合物来抑制rDNA位点的polI依赖性转录。也是WICH复合体的重要组成部分，是一种染色质重塑复合体，它激活核小体并将不规则染色质重新配置为规则的核小体阵列结构。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:2000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Mouse IgG H&L (HRP) Lysate: 1: MCF-7 Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 120 kDa Observed MW: 120 kDa Cell line: HeLa Fixative: 4% Paraformaldehyde Permeabilization: 0.1% TritonX-100 Primary Ab dilution: 1:100 Primary incubation condition: 4°C overnight Secondary Ab: Goat Anti-Mouse IgG Nuclear counter stain: DAPI (Blue) Counter stain: Tubulin (Red) Comment: Color green is the positive signal for SLM-60253M

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