TEL: +86 571 56623320 EMAIL: [email protected]
Product Name CENPC1 Chinese Name 着丝粒蛋白C1Recombinant rabbit monoclonal anti Alias CENP-C 1; CENP-C; CENPC_HUMAN; CENPC1; Centromere autoantigen C; Centromere autoantigen C1; Centromere protein C 1; ICEN7; Interphase centromere complex protein 7; MIF2. Research Area Chromatin and nuclear signals Cyclin Epigenetics Immunogen Species Rabbit Clonality Monoclonal Clone NO. 3A7 React Species Human, Applications WB=1:500-2000 IP=1:10-50 IHC-P=1:100-500 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 107kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen Recombinant human CENPC1 protein Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.
Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Subunit:
Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts directly with CENPA.
Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.
Similarity:
Belongs to the CENPC family.
SWISS:
Q03188
Gene ID:
1060
Database links:Entrez Gene: 1060 Human
Omim: 117141 Human
SwissProt: Q03188 Human
Unigene: 479867 Human
Product Picture Sample:
Lane 1: Molt-4 (Human) Cell Lysate at 30 ug
Lane 2: HL60 (Human) Cell Lysate at 30 ug
Lane 3: SH-SY5Y (Human) Cell Lysate at 30 ug
Primary: Anti-CENPC1 (SLM-54360R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 107/62 kD
Observed band size: 100 kD
Scan Wechat Qrcode