Product Name	HMGCR
Chinese Name	HMGCRRecombinant rabbit monoclonal anti
Alias	3 hydroxy 3 methylglutaryl CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3 hydroxymethylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Hydroxymethylglutaryl CoA reductase; LDLCQ3; MGC103269.
literatures	Specific References  (6)     |     SLM-52822R has been referenced in 6 publications. [IF=7.422] Han Zeng. et al. CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing. Mol Metab. 2021 Dec;:101428  WB,IP ;  Mouse,Human.   PubMed:34974159 [IF=6.317] Mubai Sun. et al. Black bean husk and black rice anthocyanin extracts modulated gut microbiota and serum metabolites for improvement in type 2 diabetic rats. FOOD FUNCT. 2022 Jun;:  WB ;  Rat.   PubMed:35730792 [IF=4.081] Huo Yihui. et al. Effect of Copper Exposure on the Cholesterol Metabolism in Broiler Liver. BIOL TRACE ELEM RES. 2023 Mar;:1-9  WB ;  Chicken.   PubMed:36929115 [IF=2.838] Min-Ho Lee. et al. Ethanol Extract of Pinus koraiensis Leaves Mitigates High Fructose-Induced Hepatic Triglyceride Accumulation and Hypertriglyceridemia. APPL SCI-BASEL. 2022 Jan;12(13):6745  WB ;  Human, Rat.   PubMed:10.3390/app12136745 [IF=2.65] Huiming Hu. et al. The Hypolipidemic Effect of Hawthorn Leaf Flavonoids through Modulating Lipid Metabolism and Gut Microbiota in Hyperlipidemic Rats.. EVID-BASED COMPL ALT. 2022 Nov;2022:3033311-3033311  WB ;  Rat.   PubMed:36425260 [IF=2.629] Mei Hui. et al. The Hypolipidemic Effect of Dalbergia odorifera T. C. Chen Leaf Extract on Hyperlipidemic Rats and Its Mechanism Investigation Based on Network Pharmacology. Evid-Based Compl Alt. 2021;2021:3155266  WB ;  Rat.   PubMed:34987591
Research Area	Tumour  Cell biology  immunology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	7C5
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:1000-2000 IP=1:10-50  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	97kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HMGCR
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Function: This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis. Subunit: Homodimer. Subcellular Location: Endoplasmic reticulum membrane. Peroxisome membrane. Similarity: Belongs to the HMG-CoA reductase family. SWISS: P04035 Gene ID: 3156 Database links: Entrez Gene: 3156 Human Entrez Gene: 15357 Mouse Entrez Gene: 25675 Rat Omim: 142910 Human SwissProt: P04035 Human SwissProt: Q01237 Mouse SwissProt: P51639 Rat Unigene: 628096 Human Unigene: 643495 Human Unigene: 316652 Mouse Unigene: 9437 Rat
Product Picture	Sample: Lane 1: Human THP-1 cell lysates Lane 2: Human HepG2 cell lysates Lane 3: Human Molt-4 cell lysates Primary: Anti- HMGCR (SLM-52822R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 97 kDa Observed band size: 105 kDa Sample: Lane 1: SiHa (Human) Cell Lysate at 30 ug Lane 2: Jurkat (Human) Cell Lysate at 30 ug Lane 3: HepG2 (Human) Cell Lysate at 30 ug Primary: Anti-HMGCR (SLM-52822R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 97 kD Observed band size: 97 kD

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