Product Name	MRC1
Chinese Name	巨噬细胞甘露糖受体 (CD206)Recombinant rabbit monoclonal anti
Alias	Mannose Receptor; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; MRC1_HUMAN; Macrophage mannose receptor 1; MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1.
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor  The cell membrane受体  glycoprotein
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	CD206
React Species	Human,  (predicted: Mouse, )
Applications	WB=1:500-2000 ICC=1:100-500 IF=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	166/140kDa
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Macrophage mannose receptor 1: 1400-1456/1456
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq] Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. Subcellular Location: Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Similarity: Contains 8 C-type lectin domains. Contains 1 fibronectin type-II domain. [SIMILARITY] Contains 1 ricin B-type lectin domain. SWISS: P22897 Gene ID: 4360 Database links: Entrez Gene: 4360 Human Entrez Gene: 17533 Mouse Entrez Gene: 291327 Rat Omim: 153618 Human SwissProt: P22897 Human SwissProt: Q61830 Mouse Unigene: 75182 Human Unigene: 2019 Mouse 巨噬细胞甘露糖受体,主要存在于巨噬The cell membrane表面的模式识别受体，能够特异性识别甘露糖、岩藻糖或N-乙酰葡糖胺，介导巨噬细胞吞噬抗原，启动免疫反应.
Product Picture	Sample: Lane 1: HepG2 (Human) Cell Lysate at 30 ug Lane 2: Hela (Human) Cell Lysate at 30 ug Lane 3: 293T (Human) Cell Lysate at 30 ug Lane 4: MCF-7 (Human) Cell Lysate at 30 ug Lane 5: Molt-4 (Human) Cell Lysate at 30 ug Primary: Anti-Macrophage mannose receptor 1 (SLM-52791R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 180-200 kD Observed band size: 185 kD

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