Rabbit Anti-Caspase-6 antibody
Apoptosis-related cysteine protein; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Huma
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Product Name Caspase-6 Chinese Name Caspase-6Recombinant rabbit monoclonal anti Alias Apoptosis-related cysteine protein; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Human cysteine protease Mch2 isoform alpha; Mch 2; Mch2; CASP6_HUMAN. 半胱胺酸蛋白酶蛋白-6蛋白 Research Area Cell biology Apoptosis Immunogen Species Rabbit Clonality Monoclonal Clone NO. 10F5 React Species Human, Mouse, Rat, Applications WB=1:1000-2000 IP=1:10-50 IHC-P=1:100-500 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （Paraffin sections need antigen repair）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 33kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Caspase-6 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
Similarity:
Belongs to the peptidase C14A family.
SWISS:
P55212
Gene ID:
839
Database links:Entrez Gene: 839 Human
Entrez Gene: 12368 Mouse
Omim: 601532 Human
SwissProt: P55212 Human
SwissProt: O08738 Mouse
Unigene: 654616 Human
Unigene: 281379 Mouse
Unigene: 88160 Rat
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Sample:
Lane 1: MCF-7 (Human) Cell Lysate at 30 ug
Lane 2: SW480 (Human) Cell Lysate at 30 ug
Lane 3: Kidney (Rat) Lysate at 40 ug
Lane 4: Kidney (Mouse) Lysate at 40 ug
Lane 5: Large intestine (Rat) Lysate at 40 ug
Lane 6: NIH/3T3(Mouse) Cell Lysate at 30 ug
Lane 7: 293T (Human) Cell Lysate at 30 ug
Lane 8: Jurkat (Human) Cell Lysate at 30 ug
Lane 9: K562 (Mouse) Cell Lysate at 30 ug
Lane 10: 293T-UV (Human) Cell Lysate at 30 ug
Primary: Anti-Caspase-6 (SLM-52503R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 34 kD
Observed band size: 34 kD
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