Product Name	Hexokinase II
Chinese Name	己糖激酶2单克隆抗体
Alias	Hexokinase II; Hexokinase 2 muscle; Hexokinase type II; Hexokinase-2; HK 2; HK II; HK2; HKII; HxK 2; HxK2; HXK2_HUMAN; Muscle form hexokinase; DKFZp686M1669.
Research Area	Tumour  Cardiovascular  Chromatin and nuclear signals  Signal transduction  transcriptional regulatory factor  The new supersedes the old  Mitochondrion
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	S2G6
React Species	Human,
Applications	WB=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-400 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	101kDa
Cellular localization	cytoplasmic The cell membrane Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human HK2 (Hexokinase II) between 1-170 amino acids.
Lsotype	IgG1,k
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose-6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases. HXK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines. HXK II is involved in the uptake and utilization of glucose by adipose and skeletal tissues. Of the hexokinases, HXK III has the highest affinity for glucose. Glucokinase is expressed in pancreatic beta cells where it functions as a glucose sensor, determining the “set point” for insulin secretion. Function: Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Subunit: Monomer. Subcellular Location: Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding. Tissue Specificity: Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Similarity: Belongs to the hexokinase family. SWISS: P52789 Gene ID: 3099 Database links: Entrez Gene: 3099 Human SwissProt: P52789 Human
Product Picture	Sample: Lane 1: Hela cell lysates Lane 2: 293 cell lysates Lane 3: Jurkat cell lysates Primary: Anti-Hexokinase II (SLM-51659M) at 1/500~1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 101 kD Observed band size: 101 kD

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