Product Name	DPYSL5
Chinese Name	二氢嘧啶酶相关蛋白5单克隆抗体
Alias	Collapsin response mediator protein 5; CRAM; CRMP 3 associated molecule; CRMP 5; CRMP3 associated molecule; Dihydropyrimidinase like 5; Dihydropyrimidinase related protein 5; DPYS L5; DPYSL 5; DPYSL5; DRP 5; DRP5; FLJ45383; Ulip 6; Ulip6; ULIP6 protein; DPYL5_HUMAN.
Research Area	Neurobiology  Cell type markers
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	C3W1
React Species	Human, Mouse, Rat,
Applications	WB=1:500-4000 ICC=1:25 IF=1:25  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	65kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human DPYL5.
Lsotype	IgG1,k
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus. Subunit: Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4. Subcellular Location: Cytoplasm. Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. SWISS: Q9BPU6 Gene ID: 56896 Database links: Entrez Gene: 56896 Human Entrez Gene: 65254 Mouse Entrez Gene: 100910964 Rat Entrez Gene: 65208 Rat SwissProt: Q9BPU6 Human SwissProt: Q9EQF6 Mouse SwissProt: Q9JHU0 Rat
Product Picture	Sample: Lane 1: SH-SY5Y cell lysates Lane 2: Mouse brain tissue lysates Lane 3: Rat brain tissue lysates Primary: Anti-DPYSL5 (SLM-51606M) at 1/4000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 65 kD Observed band size: 65 kD SH-SY5Y cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Antibody incubation with (DPYSL5) monoclonal Antibody, Unconjugated (SLM-51606M) 1:25, 90 minutes at 37°C; followed by a conjugated Goat Anti-Mouse IgG antibody at 37°C for 90 minutes, DAPI (blue) was used to stain the cell nuclei.

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