Product Name	LAMP2
Chinese Name	溶酶体相关膜蛋白2（CD107B）单克隆抗体
Alias	CD107 antigen-like family member B; CD107b; CD107b antigen; Igp110; Igp2; LAMP 2; LAMP 2C; LAMP B; LAMP-2; LAMP2_RAT; LAMPB; LGP110; Lysosomal associated membrane protein 2C; Lysosome associated membrane glycoprotein 2 precursor; Lysosome associated membrane protein 2; Lysosome-associated membrane glycoprotein 2; Lysosome-associated membrane protein 2; MAC3.
literatures	Specific References  (1)     |     SLM-51474M has been referenced in 1 publications. [IF=7.666] Kenji Ono. et al. Calmodulin as a Key Regulator of Exosomal Signal Peptides. CELLS-BASEL. 2023 Jan;12(1):158  ICC ;  Human.   PubMed:36611951
Research Area	Tumour  Cardiovascular  Cell biology  Neurobiology  Signal transduction  The new supersedes the old  Mitochondrion
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	L3G4
React Species	Human,
Applications	WB=1:500-2000 IHC-P=1:100-500 IF=1:10-50 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	45kDa
Cellular localization	cytoplasmic The cell membrane Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human LAMP2
Lsotype	IgG1,K
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by the LAMP2 gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands and is thought to play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of the gene produces two known products, LAMP2a and LAMP2b. Isoform LAMP2a is highly expressed in placenta, lung and liver and has low expression in brain and skeletal muscle. The isoform detected by this antibody, LAMP2b, is highly expressed in skeletal muscle less so in brain, placental, lung, kidney and pancreas and has very low expression in liver. Function: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Post-translational modifications: O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans. Similarity: Belongs to the LAMP family. SWISS: P13473 Gene ID: 3920 Database links: Entrez Gene: 3920 Human SwissProt: P13473 Human
Product Picture	Sample: Lane 1: Hela cell lysates Lane 2: T47D cell lysates Lane 3: Jurkat cell lysates Primary: Anti-LAMP2 (SLM-51474M) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 45 kD Observed band size: 100 kD

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