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Product Name KMT5A Chinese Name KMT5A单克隆抗体 Alias KMT5A_HUMAN; N-lysine methyltransferase KMT5A; H4-K20-HMTase KMT5A; AltName: Full=Histone-lysine N-methyltransferase KMT5A; Lysine N-methyltransferase 5A; Lysine-specific methylase 5A; PR/SET domain-containing protein 07; PR-Set7; PR/SET07; SET domain-containing protein 8. Immunogen Species Mouse Clonality Monoclonal Clone NO. G1F8 React Species Human, Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Form Lyophilized or Liquid Concentration 1mg/ml immunogen Recombinant GST fusion protein encoding N-terminal of human SET07. Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.
Subcellular Location:
Nucleus. Chromosome. Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
Similarity:
Belongs to the histone-lysine methyltransferase family.
PR/SET subfamily.
Contains 1 SET domain.
SWISS:
Q9NQR1
Gene ID:
387893
Database links:Entrez Gene: 387893 Human
Entrez Gene: 67956 Mouse
Omim: 607240 Human
SwissProt: Q9NQR1 Human
SwissProt: Q2YDW7 Mouse
Unigene: 443735 Human
Unigene: 572262 Human
Unigene: 137966 Mouse
Unigene: 8879 Rat
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