Product Name	LOX
Chinese Name	蛋白赖氨酸-6-氧化酶单克隆抗体
Alias	LYOX_HUMAN; Protein-lysine 6-oxidase; EC:1.4.3.13; Lysyl oxidase; Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form; AAT10;
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Signal transduction
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	4C3
React Species	(predicted: Human, Mouse, Rat, Pig, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	29kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LOX
Lsotype	IgG2b
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016] Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Subcellular Location: Secreted; extracellular space Tissue Specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas. Post-translational modifications: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytically activated by BMP1 (By similarity). Similarity: Belongs to the lysyl oxidase family. SWISS: P28300 Gene ID: 4015 Database links: Entrez Gene: 396474 Chicken Entrez Gene: 4015 Human Entrez Gene: 16948 Mouse Entrez Gene: 24914 Rat Omim: 153455 Human SwissProt: Q05063 Chicken SwissProt: P28300 Human SwissProt: P28301 Mouse SwissProt: P16636 Rat Unigene: 102267 Human Unigene: 172 Mouse Unigene: 11372 Rat

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