Product Name	PDK2
Chinese Name	丙酮酸脱氢酶激酶亚型2单克隆抗体
Alias	PDHK2; Pyruvate dehydrogenase kinase isoform 2; pyruvate dehydrogenase kinase, isozyme 2; Pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial; PDK2_HUMAN.
Research Area	Tumour  Cell biology  Signal transduction  transcriptional regulatory factor  Kinases and Phosphatases  Mitochondrion
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	7E5
React Species	(predicted: Human, Mouse, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:50-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	46kDa
Cellular localization	cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human PDK2
Lsotype	IgG1
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. Function: Serine/threonine kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. Subunit: Homodimer, and heterodimer with PDK1. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). Subcellular Location: Mitochondrion matrix. Tissue Specificity: Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. Similarity: Belongs to the PDK/BCKDK protein kinase family. Contains 1 histidine kinase domain. SWISS: Q15119 Gene ID: 5164 Database links: Entrez Gene: 5164 Human Entrez Gene: 18604 Mouse Entrez Gene: 81530 Rat Omim: 602525 Human SwissProt: Q15119 Human SwissProt: Q9JK42 Mouse SwissProt: Q64536 Rat Unigene: 256667 Human Unigene: 29768 Mouse Unigene: 88597 Rat

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