Product Name	CDX2
Chinese Name	尾型同源盒转录因子2单克隆抗体
Alias	cau-dal-related homeobox transcription factor 2; Caudal type homeo box 2; Caudal type homeobox protein 2; caudal type homeobox transcription factor 2; CDX 2; CDX 3; CDX3; Homeobox protein CDX-2; Homeobox protein CDX2; CDX2_HUMAN.
literatures	Specific References  (1)     |     SLM-33063M has been referenced in 1 publications. [IF=4.175] Li Liang. et al. Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer. Cancer Cell Int. 2021 Dec;21(1):1-22  IHC ;   PubMed:33632198
Research Area	Tumour  Developmental biology  Chromatin and nuclear signals  transcriptional regulatory factor
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	5G8
React Species	Rat,  (predicted: Human, Mouse, )
Applications	WB=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CDX2
Lsotype	IgG
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. This gene is a member of the caudal-related homeobox transcription factor family that is expressed in the nuclei of intestinal epithelial cells. CDX2 is also used in diagnostic surgical pathology as a marker for gastrointestinal differentiation, especially colorectal. Function: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylation of Ser-60 mediates the transactivation capacity. Similarity: Belongs to the Caudal homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: Q99626 Gene ID: 1045 Database links: Entrez Gene: 1045 Human Entrez Gene: 12591 Mouse Entrez Gene: 66019 Rat Omim: 600297 Human SwissProt: Q99626 Human SwissProt: P43241 Mouse Unigene: 174249 Human Unigene: 20358 Mouse Unigene: 64495 Rat 核转录因子抗体 CDX2表达主要用于消化系统Tumour及癌前病变的研究。用于与Tumour的增值、分化、大小、临床分期及分化程度等关系方面的研究。CDX2是一种肠特异的转录因子，CDX2能够调节肠epithelial cells的增殖和分化，定位于肠上皮的绒毛和隐窝表面。据报道95%以上的浸润性结/直肠癌中均可检出CDX2阳性表达，也可在胃癌和卵巢黏液性腺癌中表达。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CDX2) Monoclonal Antibody, Unconjugated (ascites of SLM-33063M 5G8) at 1:2000 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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