Product Name	CD146
Chinese Name	黑色素瘤Cell adhesion moleculeCD146单克隆抗体
Alias	A32 antigen; MCAM; Melanoma adhesion molecule; Melanoma associated antigen A32; Melanoma cell adhesion molecule; MelCAM; MUC18; Sendo1; MUC18_HUMAN.  CD 146; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; S endo 1; S endo 1 endothelial associated antigen; Sendo 1 endothelial associated antigen; MUC 18; CD146 antigen; Melanoma associated antigen MUC18; Melanoma associated glycoprotein MUC18;
Research Area	Tumour  immunology  Cell adhesion molecule  Cell Surface Molecule
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	P1H12
React Species	(predicted: Human, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1µl/Tests （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	118kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	0.5mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD146
Lsotype	IgG
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MCAM (MUC18 antigen, CD146), a member of the immuoglobulin superfamily, is an intrinsic membrane glycoprotein of 110-120 kDa found on the surface of endothelial cells, bone marrow fibroblasts and various melanomas. MCAM (Melanoma adhesion molecule) has been used as a marker of tumor progression in human melanoma because expression in those tumors correlates strongly with poor prognosis and the development of metastic disease. In addition, a number of human T, B and myeloid leukemic cell lines seem to express MCAM. The close structural relationship with N-CAM and related molecules suggests that MCAM may be also a developmentally regulated cell adhesion. Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 Ig-like V-type (immunoglobulin-like) domains. SWISS: P43121 Gene ID: 4162 Database links: Entrez Gene: 4162 Human Entrez Gene: 84004 Mouse Entrez Gene: 78967 Rat Omim: 155735 Human SwissProt: P43121 Human SwissProt: Q8R2Y2 Mouse SwissProt: Q9EPF2 Rat Unigene: 599039 Human Unigene: 275003 Mouse Unigene: 2694 Rat

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