Product Name	MYH9
Chinese Name	肌球蛋白重链9抗体
Alias	non-muscle Myosin IIA; Myosin heavy polypeptide 9 non muscle; Myosin-9; Myosin9; Myosin 9; Alternative namesnon-muscle IIa; type A; Cellular myosin heavy chain; Cellular myosin heavy chain type A; DFNA 17; DFNA17; EPSTS; FTNS; MHA; MYH 2A; MYH 9; MYH9_HUMAN; MYHas8; MYHas8; MyHC 2A; MyHC-Iia; MyHC-Iia; MYHSA 2; MYHSA2; MYHSA2; Myosin 9; Myosin heavy chain 9; Myosin heavy chain 9 non muscle; Myosin heavy chain; Myosin heavy chain non muscle Iia; Myosin heavy chain nonmuscle Iia; myosin heavy polypeptide 2; NMHC II A; NMMHC A;NMMHC II a; NMMHC II-a; NMMHC IIA; NMMHC-A; NMMHC-IIA; NMMHCA; Non muscle myosin heavy chain A; Non muscle myosin heavy chain;Non muscle myosin heavy chain II A; Non muscle myosin heavy polypeptide 9; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; Nonmuscle myosin heavy chain A.
literatures	Specific References  (1)     |     SL9610R has been referenced in 1 publications. [IF=8.469] Que, Tianshi. et al. HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas. Cell Death Dis. 2021 Dec;12(12):1-12  WB,IF ;  Human.   PubMed:34887392
Research Area	Cell biology  Signal transduction  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	226kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MYH9: 151-250/1960
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Defects in MYH9 are the cause of May-Hegglin anomaly (MHA) . MHA is an autosomal dominant macrothrombocytopenia characterized by thrombocytopenia, giant platelets and leukokyte inclusions appearing as highly parallel paracrystalline bodies. Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Subunit: Interacts with PDLIM2. Interacts with SLC6A4. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1. Interacts with SVIL and HTRA3. Subcellular Location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Tissue Specificity: In the kidney, expressed in the glomeruli. Also expressed in leukocytes. Post-translational modifications: ISGylated. Similarity: Contains 1 IQ domain. Contains 1 myosin head-like domain. SWISS: P35579 Gene ID: 4627 Database links: Entrez Gene: 4627 Human Entrez Gene: 17886 Mouse Entrez Gene: 25745 Rat Omim: 160775 Human SwissProt: P35579 Human SwissProt: Q8VDD5 Mouse SwissProt: Q62812 Rat Unigene: 474751 Human Unigene: 29677 Mouse Unigene: 11385 Rat
Product Picture	Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-MYH9 (SL9610R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 226 kD Observed band size: 226 kD

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