Product Name	PDE4B
Chinese Name	磷酸二酯酶4B抗体
Alias	5''-cyclic phosphodiesterase 4B; cAMP-specific 3''; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific 3'5'-cyclic Phosphodiesterase 4B; cAMP-specific phosphodiesterase-4 B isoform; DKFZp686F2182; DPDE4; dunce-like phosphodiesterase E4; MGC126529; OTTHUMP00000010652; OTTHUMP00000010653; OTTHUMP00000010654; OTTHUMP00000010656; OTTHUMP00000232365; PDE 4B; PDE IVB; PDE32; Pde4b; PDE4B_HUMAN; PDE4B5; PDEIVB; Phosphodiesterase 4B; Phosphodiesterase 4B cAMP specific; Phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila); Phosphodiesterase-4B cAMP-specific (dunce (Drosophila)-homolog); Phosphodiesterase-4B cAMP-specific.
literatures	Specific References  (1)     |     SL9590R has been referenced in 1 publications. [IF=8.739] Hailou Zhang. et al. Synergistic effects of two natural compounds of iridoids on rapid antidepressant action by up-regulating hippocampal PACAP signaling. 2022 Mar 31  WB ;  Mouse.   PubMed:35362097
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	107kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDE4B: 1-100/736
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. Tissue Specificity: Expressed in brain, heart, lung and skeletal muscle. Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. SWISS: Q07343 Gene ID: 5142 Database links: Entrez Gene: 5142 Human Entrez Gene: 18578 Mouse Entrez Gene: 24626 Rat Omim: 600127 Human SwissProt: Q07343 Human SwissProt: P14646 Rat Unigene: 198072 Human Unigene: 20181 Mouse Unigene: 37733 Rat
Product Picture	Sample:MCF-7 (Human) cellLysate at 40 ug Primary: Anti-PDE4B(SL9590R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 107kD Observed band size: 107kD

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