Product Name	TSPEAR
Chinese Name	早期未分化视网膜及晶状体蛋白EURL抗体
Alias	C21orf14; C21orf38; C21orf7; Chromosome 21 open reading frame 38; Chromosome 21 open reading frame 91; Early undifferentiated retina and lens; EURL; Protein EURL homolog; YG81; TSEAR_HUMAN.
Research Area	Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	72kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TSPEAR/C21orf9: 581-669/669
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TSPEAR, also known as C21orf9, is a 669 amino acid secreted protein. Expressed as two isoforms produced by alternative splicing, TSPEAR contains one Thrombospondin N-terminal domain and seven EAR (epilepsy-associated repeat) domains. EAR domains are found in several proteins, including TSPEAR, encoded by genes that map within chromosome regions associated with seizure disorders. It is thought that the EAR domain plays a role in the pathogenesis of epilepsy by either binding to an unknown epileptic ligand or interfering with axon synaptogenesis. Function: C21orf91 belongs to the EURL family. There are three named isoforms. The exact function of C21orf91 remains unknown. Subcellular Location: Secreted. Similarity: Contains 7 EAR repeats. Contains 1 laminin G-like domain. SWISS: Q9NYK6 Gene ID: 54149 Database links: Entrez Gene: 54149 Human Entrez Gene: 67102 Mouse Entrez Gene: 360692 Rat SwissProt: Q9NYK6 Human SwissProt: Q9D7G4 Mouse

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