Product Name	PAR4
Chinese Name	蛋白酶激活受体4抗体
Alias	F2RL3; F2R Like Thrombin/Trypsin Receptor 3; Coagulation Factor II (Thrombin) Receptor-Like 3; Thrombin Receptor-Like 3; PAR-4; Coagulation Factor II Receptor-Like 3; Proteinase-Activated Receptor-4; Proteinase-Activated Receptor 4; Protease-Activated Receptor-4; PAR4_HUMAN;
Research Area	Cardiovascular  Cell biology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Proteinase-activated receptor 4: 191-385/385 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008] Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets. Post-translational modifications: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q96RI0 Gene ID: 9002 Database links: Entrez Gene: 9002 Human Omim: 602779 Human SwissProt: Q96RI0 Human Unigene: 137574 Human
Product Picture	Sample: Lane 1: Mouse Lung tissue lysates Lane 2: Mouse Testis tissue lysates Lane 3: Rat Lung tissue lysates Lane 4: Rat Thyroid gland tissue lysates Lane 5: Rat Testis tissue lysates Lane 6: Human K562 cell lysates Lane 7: Human THP-1 cell lysates Lane 8: Human Hela cell lysates Lane 9: Human Huvec cell lysates Primary: Anti-Proteinase-activated receptor 4/PAR4 (SL9511R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kD Observed band size: 41/38 kD

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