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Product Name CMYA2/PDE4DIP Chinese Name 心肌病相关蛋白2抗体 Alias Cardiomyopathy associated protein 2; Cardiomyopathy-associated protein 2; CMYA2; MMGL; MYOME_HUMAN; Myomegalin; Pde4dip; Phosphodiesterase 4D interacting protein; Phosphodiesterase 4D-interacting protein. Research Area Cardiovascular Signal transduction Cytoskeleton Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 265kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CMYA2/PDE4DIP: 1501-1600/2365 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.
Function:
May function as an anchor sequestering components of thecAMP-dependent pathway to Golgi and/or centrosomes (By similarity).
Subunit:
Interacts with PDE4D (By similarity).
Subcellular Location:
Golgi apparatus (By similarity). Cytoplasm,cytoskeleton, centrosome (By similarity). Cytoplasm. Nucleus.
Tissue Specificity:
Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta.
DISEASE:
Note=A chromosomal aberration involving PDE4DIP may bethe cause of a myeloproliferative disorder (MBD) associated witheosinophilia. Translocation t(1;5)(q23;q33) that forms aPDE4DIP-PDGFRB fusion protein.
Similarity:
Contains 1 NBPF domain.
SWISS:
Q5VU43
Gene ID:
9659
Database links:Entrez Gene: 9659 Human
Entrez Gene: 83679 Mouse
Omim: 608117 Human
SwissProt: Q5VU43 Human
SwissProt: Q80YT7 Mouse
Unigene: 584841 Human
Unigene: 613082 Human
Unigene: 657490 Human
Unigene: 728768 Human
Unigene: 129840 Mouse
Unigene: 48693 Rat
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