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Product Name SLC27A6 Chinese Name 脂肪酸Transporter6抗体 Alias very long-chain 2; ACSVL2; FACVL2; FATP 6; FATP-6; FATP6; Fatty acid coenzyme A ligase, very long chain 2; Fatty acid transport protein 6; Fatty-acid-coenzyme A ligase; hVLCS H1; hVLCS-H1; Long-chain fatty acid transport protein 6; S27A6_HUMAN; SLC27A6; solute carrier family 27 fatty acid transporter member 6; Solute carrier family 27 member 6; Very long chain acyl CoA synthetase homolog 1; Very long-chain acyl-CoA synthetase homolog 1; VLCS H1; VLCSH1. literatures Specific References (2) | SL9454R has been referenced in 2 publications.[IF=5.108] Yang Z et al. A pilot study on polycystic ovarian syndrome caused by neonatal exposure to tributyltin and bisphenol A in rats. Chemosphere. 2019 Sep;231:151-160. WB ; Rat.[IF=3.547] Xu P et al. Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction. Toxicology. 2019 May 29;423:112-122. WB ; Mouse.Research Area Tumour Cardiovascular immunology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Fruit Fly, (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, Zebrafish, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 70kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SLC27A6/ACSVL2: 231-330/619 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Acyl-coenzyme A synthetases (ACSs) are a large family of related enzymes known to catalyze the fundamental initial reaction in fatty acid metabolism. The ACS family is roughly characterized based on fatty acid chain length preference amongst different members. The nomenclature in the ACS family reflects this relationship and includes short-chain ACS (ACSS), medium-chain ACS (ACSM), long-chain ACS (ACSL) and very long-chain ACS (ACSVL). ACSVL family members are capable of activating both long (LCFAs) and very long-chain fatty acids (VLCFAs). There are six members of the human ACSVL subfamily, which have been described as solute carrier family 27A (SLC27A) gene products. They represent a group of evolutionarily conserved fatty acid transport proteins (FATPs) recognized for their role in facilitating translocation of long-chain fatty acids across the plasma membrane. The family nomenclature has recently been unified with their respective acyl-CoA synthetase family designations: ACSVL1 (FATP2), ACSVL2 (FATP6), ACSVL3 (FATP3), ACSVL4 (FATP1), ACSVL5 (FATP4) and ACSVL6 (FATP5). ACSVLs have unique expression patterns and are found in major organs of fatty acid metabolism, such as adipose tissue, liver, heart and kidney. ACSVL2 is a 619 amino acid multi-pass membrane protein. Encoded by a gene that maps to human chromosome 5q23.3, ACSVL2 may function as the predominant fatty acid protein transporter in heart.
Function:
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.
Subcellular Location:
Membrane. Cell membrane; sarcolemma. In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36.
Tissue Specificity:
Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.
Similarity:
Belongs to the ATP-dependent AMP-binding enzyme family.
SWISS:
Q9Y2P4
Gene ID:
28965
Database links:Entrez Gene: 28965 Human
Entrez Gene: 225579 Mouse
Omim: 604196 Human
SwissProt: Q9Y2P4 Human
Unigene: 49765 Human
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