Product Name	MURF2
Chinese Name	肌肉特异性Ring finger protein2抗体
Alias	MURF 2; MURF-2; MuRF2; Muscle specific ring finger 2; Muscle specific RING finger protein 2; Muscle-specific RING finger protein 2; ring finger protein 29; RNF 29; RNF29; TRI55_HUMAN; TRIM 55; Trim55; Tripartite motif containing 55; Tripartite motif containing protein 55; Tripartite motif-containing protein 55.
Research Area	Cell biology  Signal transduction  Cyclin  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MURF2: 65-160/548
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MuRF1 (RNF28), MuRF2 (RNF29) and MuRF3 (RNF30) are a specific class of RING finger proteins expressed in striated muscle tissues that act as signaling molecules and cytoskeletal adaptors. The MuRF proteins contain a conserved N-terminal RING domain and zinc-binding B-box motif in addition to two coiled-coil motifs in their central regions. In muscle cells, MuRF2 regulates gene expression and protein turnover. It localizes to the cytoplasm, but under atrophic conditions it is detected in the nucleus. MuRF2 can form oligomers with various other proteins, including titin and myosin, during sarcomere assembly. Endogenous MuRF2 associates with the sarcomeric M-band in cardiomyocytes. There are at least four isoforms of MuRF2. Subunit: Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54. Subcellular Location: Cytoplasm. Nucleus. Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules. Tissue Specificity: Highly expressed in muscle. Low-level expression in liver. Similarity: Contains 1 B box-type zinc finger. Contains 1 COS domain. Contains 1 RING-type zinc finger. SWISS: Q9BYV6 Gene ID: 84675 Database links: Entrez Gene: 84675 Human Entrez Gene: 381485 Mouse Entrez Gene: 365751 Rat Omim: 606469 Human SwissProt: Q9BYV6 Human SwissProt: Q5PQN5 Rat Unigene: 85524 Human Unigene: 35419 Mouse Unigene: 76142 Rat

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