Product Name	ASTE1
Chinese Name	ASTE1蛋白抗体
Alias	ASTE1; ASTE1_HUMAN; Asteroid homolog 1 (Drosophila); HT001; MGC129980; OTTHUMP00000216085; Protein asteroid homolog 1.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	77kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ASTE1: 31-130/679
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ASTE1 is a 679 amino acid protein that belongs to the asteroid family. Encoded by a gene that maps to human chromosome 3q22.1, ASTE1 is conserved in chimpanzee, cow, mouse, rat and zebrafish. ASTE1 is strongly linked to tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability, with lymphocyte density correlating to frameshift mutation presence and frequency within ASTE1. Severe colorectal dysplasia with microsatellite instability also exhibits frameshift mutations within ASTE1, suggesting that ASTE1 mutations occur early during microsatellite instability-induced colorectal carcinogenesis. ASTE1 frameshift mutations may generate a premature stop codon in the last exon that does not result in nonsense-mediated mRNA decay, thereby allowing mutated ASTE1 proteins to be highly expressed and exceptionally immunogenic. Frameshift mutations in ASTE1 are also linked to the manifestation of neoantigens, potentially recognized by T cells, possibly resulting in specific immune responses against specific neoantigens. Function: Possible role in EGF receptor signaling (By similarity). Similarity: Belongs to the asteroid family. SWISS: Q2TB18 Gene ID: 28990 Database links: Entrez Gene: 28990 Human SwissProt: Q2TB18 Human Unigene: 100878 Human

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