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Rabbit Anti-IGSF5 antibody
Rabbit Anti-IGSF5 antibody
GSF5; IgSF5; IGSF5_HUMAN; Immunoglobulin superfamily 5 like; Immunoglobulin superfamily member 5; JAM-4; Junctional adhesion molecule 4.
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Details

Product Name IGSF5
Chinese Name 免疫球蛋白超家族成员5抗体
Alias GSF5; IgSF5; IGSF5_HUMAN; Immunoglobulin superfamily 5 like; Immunoglobulin superfamily member 5; JAM-4; Junctional adhesion molecule 4.  
Research Area Cell biology  Signal transduction  Cell Surface Molecule  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 45kDa
Cellular localization The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human IGSF5: 171-270/407 <Extracellular>
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells.

Function:
Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity).

Subunit:
Interacts with MAGI1 at tight junctions, forms a tripartite complex with NPHS1 (By similarity). Interacts with LNX1 isoform 2 via its PDZ 2 domain, it may also interact with other isoforms containing this domain (By similarity).

Subcellular Location:
Cell membrane; Single-pass membrane protein (By similarity). Cell junction, tight junction (By similarity).

Similarity:
Belongs to the immunoglobulin superfamily.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.

SWISS:
Q9NSI5

Gene ID:
150084

Database links:

Entrez Gene: 150084 Human

Omim: 610638 Human

SwissProt: Q9NSI5 Human

Unigene: 422120 Human



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