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Rabbit Anti-VGLL4 antibody
Rabbit Anti-VGLL4 antibody
Transcription cofactor vestigial like protein 4; Vestigial like protein 4; VGL 4; VGLL4; VGLL4_HUMAN.
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  • NO.:SL9185R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,Rat,(predicted: Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)
    Applications:WB ELISA
    concentration:1mg/ml
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Details

Product Name VGLL4
Chinese Name 转录辅助因子退变样蛋白4抗体
Alias Transcription cofactor vestigial like protein 4; Vestigial like protein 4; VGL 4; VGLL4; VGLL4_HUMAN.  
Research Area Cell biology  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 31kDa
Cellular localization The nucleus 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human VGLL4: 201-290/290 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail The transcriptional enhancer factor-1 (TEF-1) family of transcription factors regulate tissue-specific gene expression in muscle and placenta. The mechanism whereby TEF-1 confers tissue specificity depends largely on the interaction of TEF-1 with tissue-specific cofactors. Transcription cofactor Vgl-4 (vestigial-like protein 4) is a 290 amino acid nuclear protein that interacts with TEF-1 and MEF-2. Vgl-4 is the only member of the vestigial-like family that is expressed in heart. Overexpression of Vgl-4 in cardiac myocytes interferes with basal expression and ?-adrenergic receptor-dependent activation of a TEF-1 dependent skeletal ?actin promoter. This suggests that Vgl-4 counteracts ?-adrenergic activation of gene expression in cardiomyocytes. There are two isoforms of Vgl-4 that are produced as a result of alternative splicing events.

Function:
May act as a specific coactivator for the mammalian TEFs (By similarity).

Subunit:
Interacts with TEFs (By similarity). Interacts with IRF2BP2.

Subcellular Location:
Nuclear

Similarity:
Belongs to the vestigial family.

SWISS:
Q14135

Gene ID:
9686

Database links:

Entrez Gene: 9686 Human

Entrez Gene: 232334 Mouse

Entrez Gene: 297523 Rat

SwissProt: Q14135 Human

SwissProt: Q80V24 Mouse

Unigene: 23131 Rat



Product Picture
Sample:
Lane 1: Mouse Stomach tissue lysates
Lane 2: Mouse Lung tissue lysates
Lane 3: Mouse Large intestine tissue lysates
Primary: Anti-VGLL4 (SL9185R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kDa
Observed band size: 31 kDa
Sample:
Ovary (Mouse) Lysate at 40 ug
Ovary (Rat) Lysate at 40 ug
Primary: Anti-VGLL4 (SL9185R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 31 kD

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