Product Name	Repetin
Chinese Name	中间丝相关蛋白抗体
Alias	Intermediate filament associated protein; RPTN; RPTN_HUMAN.
Research Area	Cell biology  Signal transduction  Cyclin  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	91kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Repetin: 41-140/784
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Repetin is a 784 amino acid secreted protein that belongs to the S100-fused protein family. Repetin is an extracellular epidermal matrix protein that is expressed in the epidermis and at high levels in eccrine sweat glands, the inner sheaths of hair roots and the filiform papilli of the tongue. A multifunctional epidermal matrix protein, repetin is involved in the cornified cell envelope formation. Containing two EF-hand domains, repetin’s recombinant N-terminal domain binds calcium reversibly. Repetin and trichohyalin may compensate for absent loricrin. The repetin gene contains three exons, two introns and spans at least 5.6 kb. The repetin gene is conserved in cow, mouse and rat, and maps to human chromosome 1q21.3. Function: Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. Subcellular Location: Secreted; extracellular space; extracellular matrix. Tissue Specificity: Repetin is a multifunctional epidermal matrix protein involved in the cornified cell envelope formation. It reversibly binds calcium. Expression is scattered in the normal epidermis but strong in the acrosyringium, the inner hair root sheat and in the filiform papilli of the tongue. Post-translational modifications: Potential substrate of transglutaminase. Some arginines are probably converted. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the S100-fused protein family. Contains 2 EF-hand domains. SWISS: Q6XPR3 Gene ID: 126638 Database links: Entrez Gene: 126638 Human Entrez Gene: 20129 Mouse Omim: 613259 Human SwissProt: Q6XPR3 Human SwissProt: P97347 Mouse Unigene: 376144 Human
Product Picture	Sample: A431(human) cell Lysate at 40 ug Primary: Anti- repetin (SL9181R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 91kD Observed band size: 91 kD Sample: Hela(human)cell Lysate at 40 ug Primary: Anti- repetin (SL9181R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 91kD Observed band size: 91 kD

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