Product Name	AKIRIN1
Chinese Name	AKIRIN1蛋白抗体
Alias	AKIRIN 1; C1orf108; FLJ12666; OTTHUMP00000008669; RP11-781D11.2; STRF2; AKIR1_HUMAN.
Research Area	Cell biology  immunology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human AKIRIN1: 101-192/192
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. Subcellular Location: Nuclear Tissue Specificity: Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes. Similarity: Belongs to the akirin family. SWISS: Q9H9L7 Gene ID: 79647 Database links: Entrez Gene: 79647 Human Entrez Gene: 68050 Mouse Entrez Gene: 595134 Rat Omim: 615164 Human SwissProt: Q9H9L7 Human SwissProt: Q99LF1 Mouse Unigene: 293563 Human Unigene: 27903 Mouse Unigene: 390996 Mouse Unigene: 486258 Mouse Unigene: 3674 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AKIRIN1) Polyclonal Antibody, Unconjugated (SL9081R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AKIRIN1) Polyclonal Antibody, Unconjugated (SL9081R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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