Product Name	CD34
Chinese Name	CD34抗体
Alias	CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN.
literatures	Specific References  (8)     |     SL8996R has been referenced in 8 publications. [IF=4.996] Yang Dapeng. et al. Morphological and histochemical identification of telocytes in adult yak epididymis. SCI REP-UK. 2023 Mar;13(1):1-14  IHC ;  Bovine.   PubMed:37002252 [IF=4.982] Tian Jing. et al. linc00958/miR-185-5p/RSF-1 modulates cisplatin resistance and angiogenesis through AKT1/GSK3β/VEGFA pathway in cervical cancer. REPROD BIOL ENDOCRIN. 2022 Dec;20(1):1-12  IHC ;  Mouse.   PubMed:36056431 [IF=4.714] Emma Heyman. et al. Validation of multiparametric panels for bovine mesenchymal stromal cell phenotyping. CYTOM PART A. 2023 May;:  FCM ;  Bovine.   PubMed:37173856 [IF=3.26] Lee, So‐Youn, et al. "Comparison of dextran‐based sirolimus‐eluting stents and PLA‐based sirolimus‐eluting stents in vitro and in vivo." Journal of Biomedical Materials Research Part A (2016).  IHC-P ;  Pig.   PubMed:27615559 [IF=3.04] Tawfik KM et al. Neuroprotective mechanisms of sildenafil and selenium in PTZ-kindling model: Implications in epilepsy.Eur J Pharmacol. 2018 Aug 15;833:131-144.  IHC-P ;  Mouse.   PubMed:29807031 [IF=2.792] Yan, Wei. et al. Neural, adipocyte and hepatic differentiation potential of primary and secondary hair follicle stem cells isolated from Arbas Cashmere goats. BMC VET RES. 2022 Dec;18(1):1-18  IF, WB ;  Goat.   PubMed:35971123 [IF=0.84] Cui, Dan-dan, et al. "Effects of Bu-Shen-An-Tai recipe and its two components on endometrial morphology during peri-implantation in superovulated mice." Journal of Huazhong University of Science and Technology [Medical Sciences] 34 (2014): 768-774.  IHC-P ;  Mouse.   PubMed:25318891 [IF=0.17] W Jiang et al. EFFECTS OF MESENCHYMAL STEM CELL TRANSPLANTATION INTO ISCHEMIC BILE DUCT INJURY TISSUES OF RATS ON THE EXPRESSION OF VASCULAR DENSITY. Slov Vet Res 2019: 56 (4): 183–90.  IHC-P ;  Rat.   PubMed:DOI:10.26873/SVR-844-2019
Research Area	Tumour  Cardiovascular  Cell biology  Neurobiology  Stem cells  Cell Surface Molecule  vascular endothelial cell
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	39kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD34: 181-280/385 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Post-translational modifications: Highly glycosylated. Phosphorylated on serine residues by PKC. Similarity: Belongs to the CD34 family. SWISS: P28906 Gene ID: 947 Database links: UniProtKB/Swiss-Prot: P28906.2
Product Picture	Tissue/cell: mouse kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CD34 Polyclonal Antibody, Unconjugated(SL8996R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Blank control: Raji(blue). Primary Antibody:Rabbit Anti-CD34 antibody(SL8996R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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