Product Name	CD36
Chinese Name	CD36抗体
Alias	Platelet glycoprotein 4; PAS-4; Platelet glycoprotein IV; Glycoprotein IIIb; GPIV; GPIIIB; GP3B; Leukocyte differentiation antigen CD36; PAS IV; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor; CD_antigen: GP4; CD36_HUMAN.
literatures	Specific References  (8)     |     SL8873R has been referenced in 8 publications. [IF=8.071] Xiaohui Xu. et al. Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha. Environ Pollut. 2021 Dec;290:118112  WB ;  chicken.   PubMed:34500398 [IF=6.832] Yanhong Li. et al. Therapeutic potential of human umbilical cord mesenchymal stem cells on aortic atherosclerotic plaque in a high-fat diet rabbit model. Stem Cell Res Ther. 2021 Dec;12(1):1-14  IHC ;  Rabbit.   PubMed:34266502 [IF=6.208] Ziyi Pan. et al. A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression. INT J MOL SCI. 2023 Jan;24(2):1180  WB ;  Duck.   PubMed:36674699 [IF=5.923] Dashdulam Davaanyam. et al. Intranasal Delivery of RGD-Containing Osteopontin Heptamer Peptide Confers Neuroprotection in the Ischemic Brain and Augments Microglia M2 Polarization. Int J Mol Sci. 2021 Jan;22(18):9999  WB ;  Mouse.   PubMed:10.3390/ijms22189999 [IF=5.595] Sheng L et al. Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila.FASEB J. 2018 Jun 8:fj201800370R.  WB ;  Mouse.   PubMed:29882708 [IF=3.998] Fang JY et al. Switch of macrophage fusion competency by 3D matrices. Sci Rep. 2020 Jun 25;10(1):10348.  ICC ;  Mouse.   PubMed:32587271 [IF=2.559] Weinheimer C et al. Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat. Reprod Sci. 2020 Jan 6.  WB ;  Rat.   PubMed:32046449 [IF=1.632] Liu Y et al. Isolation and characterization of ovine monocyte-derived macrophages from peripheral blood.(2018)Vet Immunol Immunopathol. Nov;205:83-92.  IF ;  Sheep.   PubMed:30459005
Research Area	Tumour  Cell biology  Signal transduction  Stem cells  Cell Surface Molecule  Cell type markers  vascular endothelial cell  endothelial cells  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD36/PAS-4: 351-430/472 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014] Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects. Subunit: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Subcellular Location: Membrane; Multi-pass membrane protein. Post-translational modifications: N-glycosylated and O-glycosylated with a ratio of 2:1. DISEASE: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938]. Similarity: Belongs to the CD36 family. SWISS: P16671 Gene ID: 948 Database links: Entrez Gene: 948 Human Entrez Gene: 12491 Mouse Entrez Gene: 29184 Rat Omim: 173510 Human SwissProt: P16671 Human SwissProt: Q08857 Mouse SwissProt: Q07969 Rat Unigene: 120949 Human Unigene: 18628 Mouse Unigene: 406799 Mouse Unigene: 102418 Rat Unigene: 205840 Rat CD36属一种多功能The cell membrane受体，CD36参与长链脂肪酸的吸附和调节Apoptosis残物的清理和巨噬细胞的吞噬作用， 属于一种抗蛋白酶血小板膜表面glycoprotein。 CD36 广泛在单核细胞、巨噬细胞、内皮层细胞、血小板、红细胞前板、脂肪细胞、肌肉细胞以及乳腺内皮层细胞中有不同的表达。CD36抗原是血小板反应素的配体，两者结合后产生抑制Tumour血管生成的效应。
Product Picture	Sample: Lane 1: Mouse Placenta tissue lysates Lane 2: Mouse Raw264.7 cell lysates Lane 3: Rat Placenta tissue lysates Lane 4: Human HUVEC cell lysates Lane 5: Human HL-60 cell lysates Primary: Anti-CD36 (SL8873R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 100 kDa

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