Product Name	STOML2
Chinese Name	溴化丙胺太林相关蛋白2抗体
Alias	EPB72 like protein 2; HSPC108; OTTHUMP00000021320; SLP 2; SLP2; SLP-2; Stomatin (EPB72) like 2; Stomatin like 2; Stomatin like protein 2; STOML2; STML2_HUMAN.
literatures	Specific References  (1)     |     SL8861R has been referenced in 1 publications. [IF=3.177] Xue Zhang. et al. Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions. Placenta. 2020 Oct;100:13  WB,IF,IHC ;   PubMed:32814233
Research Area	Tumour  Cardiovascular  Cell biology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	39kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human STOML2/SLP2: 251-356/356
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	STOML2 is a 356 amino acid member of the mec-2 family of proteins. Expressed ubiquitously at low levels, STOML2 is highly expressed in heart, liver and pancreas. STOML2 is localized to the cytoplasm with some distribution on the membrane. STOML2 was first identified as an overexpressed protein in human endometrial adenocarcinoma. Changes in cell growth in samples with different levels of STOML2 indicate that STOML2 could play a role in endometrial tumorigenesis. STOML2 is also thought to play a role in regulating ion channel conductances or the organization of sphingolipid and cholesterol-rich lipid rafts. Function: STOML2 is similar in sequence to stomatin. It is a 356 amino acid protein with a calculated molecular mass of 38.5 kDa. STOML2 has 3 potential initiator sites, all sharing the same open reading frame. The STOML2 protein contains the cognate stomatin family consensus sequence, but it lacks the characteristic N-terminal hydrophobic domain and palmitoylation consensus sequence. STOML2 shares greatest sequence homology with stomatin and SLP1 in a region predicted to contain beta sheet and alpha helix structures. Northern blot analysis detected a 1.5 kb STOML2 transcript in all tissues examined, with highest levels in heart, liver, and pancreas. Western blot analysis detected STOML2 at apparent molecular masses of 45.5 kDa or 44.6 kDa in all human and mammalian cell lines and tissues examined, including red blood cells. Some cells also showed a faint band at about 34.3 kDa, which may represent translation from an alternate initiation site. Subcellular Location: Membrane; peripheral membrane protein. Cytoplasm. Associated with the cytoskeleton. Tissue Specificity: Ubiquitously expressed at low levels. Similarity: Belongs to the band 7/mec-2 family. SWISS: Q9UJZ1 Gene ID: 30968 Database links: Entrez Gene: 30968 Human Entrez Gene: 66592 Mouse Entrez Gene: 298203 Rat Omim: 608292 Human SwissProt: Q9UJZ1 Human SwissProt: Q99JB2 Mouse SwissProt: Q4FZT0 Rat Unigene: 3439 Human Unigene: 331565 Mouse Unigene: 2208 Rat
Product Picture	Sample: Hela(Human) Cell Lysate at 30 ug Siha(Human) Cell Lysate at 30 ug Primary: Anti-STOML2 (SL8861R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 39 kD Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (STOML2) Polyclonal Antibody, Unconjugated (SL8861R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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