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Product Name Synaptopodin 2 Chinese Name 突触足蛋白2抗体 Alias DKFZp686G051; Genethonin 2; Genethonin-2; Myopodin; striated muscle specific; Synaptopodin-2; SYNP2_HUMAN; SYNPO 2; Synpo2. Research Area Tumour Cell biology Signal transduction Binding protein Cytoskeleton Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 117kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Synaptopodin 2: 601-700/1093 Lsotype IgG Purification affinity purified by Protein A Buffer Solution Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail SYNPO2 (Synaptopodin 2) is a Protein Coding gene. Diseases associated with SYNPO2 include Duchenne Muscular Dystrophy and Myopathy, Myofibrillar, 2. GO annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is SYNPO2L.
Function:
Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).
Subcellular Location:
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly overlapping with filamentous actin.
Tissue Specificity:
Skeletal muscle-specific.
DISEASE:
Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD).
Similarity:
Belongs to the synaptopodin family.
Contains 1 PDZ (DHR) domain.
SWISS:
Q9UMS6
Gene ID:
171024
Database links:Entrez Gene: 171024 Human
Entrez Gene: 118449 Mouse
SwissProt: Q9UMS6 Human
SwissProt: Q91YE8 Mouse
Unigene: 655519 Human
Unigene: 317009 Mouse
Unigene: 34359 Mouse
Unigene: 474733 Mouse
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