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Product Name ALKBH7 Chinese Name AlkB同源蛋白7抗体 Alias ABH7; ALKB7_HUMAN; ALKBH7; Alkylated DNA repair protein alkB homolog 7; MGC10974; Probable alpha-ketoglutarate-dependent dioxygenase ABH7; SPATA11; Spermatogenesis cell proliferation-related protein; Spermatogenesis-associated protein 11; UNQ6002; UNQ6002/PRO34564. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 22kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ALKBH7: 21-120/221 Lsotype IgG Purification affinity purified by Protein A Buffer Solution Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.
Function:
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
Subcellular Location:
Cytoplasm. Nucleus. Secreted. Has a predicted N-terminal signal sequence, indicating it may be secreted. Detected in cytoplasm and nucleus when expressed as fusion protein with an N-terminal tag.
Tissue Specificity:
Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
Similarity:
Belongs to the alkB family.
SWISS:
Q9BT30
Gene ID:
84266
Database links:Entrez Gene: 84266 Human
Omim: 613305 Human
SwissProt: Q9BT30 Human
Unigene: 111099 Human
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