Product Name	PTPD2
Chinese Name	Cytoskeleton相关蛋白酪氨酸磷酸酶2抗体
Alias	Cytoskeletal associated protein tyrosine phosphatase; MGC126803; PEZ; Phosphatase with ezrin domain; Protein tyrosine phosphatase non receptor type 14; Protein tyrosine phosphatase pez; Protein-tyrosine phosphatase pez; PTN14_HUMAN; PTP 36; PTP36; PTPD 2; PTPN 14; PTPN14; Tyrosine protein phosphatase non receptor type 14; Tyrosine-protein phosphatase non-receptor type 14.
Research Area	Cell biology  Signal transduction  Kinases and Phosphatases  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	135kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PTPD2: 951-1029/1029
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010] Function: Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis. Subcellular Location: Cytoplasm > cytoskeleton. Tissue Specificity: Expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Defects in PTPN14 are a cause of choanal atresia and lymphedema (CHATLY) [MIM:613611]. A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. Note=A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 tyrosine-protein phosphatase domain. SWISS: Q15678 Gene ID: 5784 Database links: Entrez Gene: 5784 Human Omim: 603155 Human SwissProt: Q15678 Human Unigene: 193557 Human

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