Product Name	Spermine synthase
Chinese Name	精胺合成酶抗体
Alias	MRSR; SMS; Snyder Robinson X linked mental retardation syndrome; Spermidine aminopropyltransferase; Spermine synthase; SPMSY; SpS; SPSY_HUMAN; SRS.
Research Area	Tumour  Developmental biology  Signal transduction  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Spermine synthase: 245-350/366
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Spermine synthase catalyzes the production of spermine from spermidine. Spermine, a polyamine ubiquitously present in most organisms, is essential for normal cell growth and differentiation. Because absence of spermine increases sensitivity of cells to anti-tumor agents, spermine synthase (and other polyamine biosynthesis) is an attractive target for anti-neoplastic therapy. Function: Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). Subunit: Homodimer. Dimerization is mediated through the N-terminal domain and seems to be required for activity as deletion of the N-terminal domain causes complete loss of activity. DISEASE: efects in SMS are the cause of X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR) [MIM:309583]. Characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive. Similarity: Belongs to the spermidine/spermine synthase family. SWISS: P52788 Gene ID: 6611 Database links: Entrez Gene: 6611 Human Entrez Gene: 20603 Mouse Entrez Gene: 671878 Mouse Entrez Gene: 363469 Rat Omim: 300105 Human SwissProt: P52788 Human SwissProt: P97355 Mouse
Product Picture	Sample: Raw264.7 (Mouse) Cell Lysate at 30 ug Spleen (Mouse) Lysate at 40 ug Primary: Anti- Spermine synthase (SL8681R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kD Observed band size: 46 kD

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