Product Name	GIPC-2
Chinese Name	胞浆区相关蛋白GIPC2抗体
Alias	GIPC 2; GIPC-2 GIPC PDZ domain containing family, member 2; GIPC2; GIPC2_HUMAN; Likely ortholog of mouse semaF cytoplasmic domain associated protein 2; PDZ domain protein GIPC2; PDZ domain-containing protein GIPC2; SemaF cytoplasmic domain associated protein 2; Semaphorin cytoplasmic domain associated protein 2; SEMCAP 2; SEMCAP2.
literatures	Specific References  (1)     |     SL8586R has been referenced in 1 publications. [IF=4.136] Min Kang. et al. Increased expression of GIPC2 in colon adenocarcinoma is associated with a favorable prognosis and high levels of immune cell infiltration. ONCOL REP. 2023 Apr;49(4):1-11  IHC ;  Human.   PubMed:36799193
Research Area	Tumour  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GIPC2: 201-300/315
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GIPC2 is a 315 amino acid protein that localizes to the cytoplasm and contains one PDZ domain. Expressed at high levels in kidney and colon and at lower levels in adult liver, GIPC2 interacts with SEMA5A and is thought to function as a scaffold protein, possibly modulating cell adhesion and growth factor signaling and playing a role in tumorigenesis. The gene encoding GIPC2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Subunit: Probably interacts with SEMA5A (By similarity). . Subcellular Location: Cytoplasm. Tissue Specificity: Expressed at highest levels in ascending colon and at moderate levels in adult kidney. Expressed at low levels in adult pancreas and at very low levels in adult liver. Expression is down-regulated in several primary tumors, such as kidney, colon and rectal tumors. Similarity: Contains 1 PDZ (DHR) domain. SWISS: Q8TF65 Gene ID: 54810 Database links: Entrez Gene: 54810 Human Entrez Gene: 54120 Mouse Entrez Gene: 365960 Rat SwissProt: Q8TF65 Human SwissProt: Q9Z2H7 Mouse SwissProt: Q498D9 Rat Unigene: 659356 Human Unigene: 97 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GIPC-2) Polyclonal Antibody, Unconjugated (SL8586R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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