Product Name	GNAI2/G protein alpha inhibitor 1
Chinese Name	G蛋白α抑制蛋白1抗体
Alias	G alpha i-1; G Protein alpha Inhibitor 1; Adenylate cyclase inhibiting G alpha; Gi; Gi1 protein alpha subunit; Gi2 protein alpha subunit; GIP; GNAI1; GNAI2; GNAI2B; Guanine nucleotide binding protein G(i) alpha 1 subunit; Guanine nucleotide binding protein G(i) alpha 2 subunit; GNAI2_HUMAN; Adenylate cyclase inhibiting G alpha protein; Adenylate cyclase-inhibiting G alpha protein; GNAI 2; Gnai2; GTP binding regulatory protein Gi alpha 2 chain; Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding protein G(i) subunit alpha-2; H LUCA15.1; H LUCA16.1; WUGSC:H LUCA15.1; WUGSC:H LUCA16.1.
literatures	Specific References  (1)     |     SL8556R has been referenced in 1 publications. [IF=2.4] Afifiyan, N., et al. "The role of Tec kinase signaling pathways in the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis." Experimental and Molecular Pathology (2017)  IHC-P ;  Human.   PubMed:28935395
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human G Protein alpha Inhibitor 1: 265-355/355
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The G protein family of signal transducers includes 5 heterotrimers, which are most clearly distinguished by their different alpha chains; they have virtually identical beta chains and similar gamma chains. G protein alpha inhibitor chains 1 and 2 are subunits of the G(i) G protein, whose role is in inhibiting adenylate cyclase activity in response to bound GTP. Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14. Interacts with UNC5B. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cell membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. Similarity: Belongs to the G-alpha family. G(i/o/t/z) subfamily. SWISS: P04899 Gene ID: 2771 Database links: Entrez Gene: 2771 Human Entrez Gene: 14678 Mouse Entrez Gene: 81664 Rat Omim: 139360 Human SwissProt: P04899 Human SwissProt: P08752 Mouse SwissProt: P04897 Rat Unigene: 77269 Human Unigene: 196464 Mouse Unigene: 3036 Rat Gα i-1/2/3
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GNAI2 G protein alpha inhibitor 1) Polyclonal Antibody, Unconjugated (SL8556R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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