Product Name	EP4
Chinese Name	前列腺素E受体蛋白4抗体
Alias	Prostaglandin E Receptor EP4; EP 4; EP4; EP-4; EP4R; MGC126583; PE2R4_HUMAN; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostaglandin E receptor 4; Prostaglandin E receptor 4 subtype EP4; Prostaglandin E2 receptor; Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor; PTGER 2; PTGER 4; PTGER2; PTGER4.
literatures	Specific References  (8)     |     SL8538R has been referenced in 8 publications. [IF=9.423] Xi He. et al. Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche. Cell Rep. 2021 Sep;36:109674  IF ;  mouse.   PubMed:34496236 [IF=7.01] Xin Wang. et al. Irreversible Electroporation Improves Tendon Healing in a Rat Model of Collagenase-Induced Achilles Tendinopathy. AM J SPORT MED. ;():  IHC,IF ;  Rat.   PubMed:37129100 [IF=4.622] Seung-Yub Song. et al. Purification of phenoloxidase from Haliotis discus hannai and its anti-inflammatory activity in vitro. FISH SHELLFISH IMMUN. 2023 Jun;137:108741  WB ;  Human.   PubMed:37088346 [IF=4.5] Koyama, Hiroyuki, et al. "Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells." Endocrinology (2016): en-2016.  IHC-P ;  Mouse.   PubMed:26671185 [IF=3.23] Takemiya et al. Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis. (2017) Int.J.Mol.Sci. 18  IHC-F ;  Mouse.   PubMed:29257087 [IF=2.38] Hu, Ruiqi, et al. "The expression of prostaglandin-E2 and its receptor in the oviduct of Chinese brown frog (Rana dybowskii)." Prostaglandins & Other Lipid Mediators (2016).  IHC-P ;  Others.   PubMed:27246901 [IF=2.253] Chen Z et al. Seasonal expressions of prostaglandin E synthases and receptors in the prostate of the wild ground squirrel (Spermophilus dauricus). Prostaglandins and Other Lipid Mediators 148 (2020) 106412.  IHC-P ;  squirrel.   PubMed:doi:10.1016/j.prostaglandins.2020.106412 [IF=2.253] Wang Y et al. Seasonal expressions of COX-1, COX-2 and EP4 in the uteri of the wild Daurian ground squirrels (Spermophilus dauricus). Prostaglandins Other Lipid Mediat. 2019 Aug;143:106343.  IHC&WB ;  squirrel.   PubMed:31195125
Research Area	Signal transduction  G protein-coupled receptor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Bee, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EP4R/Prostaglandin E Receptor EP4: 151-250/488 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Function: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Subunit: Interacts with FEM1A. Subcellular Location: Cell membrane. Tissue Specificity: High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle. Post-translational modifications: Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P35408 Gene ID: 5734 Database links: Entrez Gene: 5734 Human Entrez Gene: 19219 Mouse Entrez Gene: 84023 Rat Entrez Gene: 443222 Sheep Omim: 601586 Human SwissProt: P35408 Human SwissProt: P32240 Mouse SwissProt: P43114 Rat Unigene: 199248 Human Unigene: 18509 Mouse Unigene: 16062 Rat
Product Picture	Sample: Raji(Human) Cell Lysate at 30 ug Primary: Anti-EP4  (SL8538R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53 kD Sample: Lane 1: Mouse Lung tissue lysates Lane 2: Rat Cerebrum tissue lysates Lane 3: Rat Esophagus tissue lysates Lane 4: Rat Liver tissue lysates Primary: Anti-EP4 (SL8538R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 60 kD Sample: MCF-7 Cell (Human) Lysate at 30 ug Primary: Anti-EP4 (SL8538R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53 kD Blank control (blue line): Hela (fixed with 70% methanol (Overnight at -20℃) and then permeabilized with ice-cold 90% methanol for 30 min on ice). Primary Antibody (green line): Rabbit Anti-EP4 antibody (SL8538R),Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-FITC,Dilution: 1μg /test.

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