TEL: +86 571 56623320 EMAIL: [email protected]
Product Name FNDC3B Chinese Name Ⅲ型纤维连接蛋白域蛋白3B抗体 Alias Factor for adipocyte differentiation 104; FAD104; fibronectin type III domain containing 3B; FLJ23399; HCV NS5A binding protein 37; NS5ABP37; YVTM2421; MGC10002; PRO4979; DKFZp686D14170; DKFZp762K137; FND3B_HUMAN. Research Area Tumour Cell biology immunology Signal transduction Stem cells Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 133kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FNDC3B: 921-1020/1204 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.
Function:
May be a positive regulator of adipogenesis.
Subcellular Location:
Membrane; Single pass membrane protein
Tissue Specificity:
Predominantly expressed in white adipose tissue (WAT) especially in the stromal vascular cells. Expressed in adipocyte differentiable 3T3-L1 cells but not in the non-adipogenic cell line NIH-3T3. Expression increased in the early stage of adipogenesis.
Similarity:
Belongs to the FNDC3 family.
Contains 9 fibronectin type-III domains.
SWISS:
Q53EP0
Gene ID:
64778
Database links:Entrez Gene: 64778 Human
Omim: 611909 Human
SwissProt: Q53EP0 Human
Scan Wechat Qrcode